| HNF4A |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1PZL, 3CBB, 3FS1, 4B7W, 4IQR | | |
| Ідентифікатори |
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| Символи | HNF4A, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14, FRTS4, Hepatocyte nuclear factor 4 alpha, TCF-14 |
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| Зовнішні ІД | OMIM: 600281 MGI: 109128 HomoloGene: 395 GeneCards: HNF4A |
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| Пов'язані генетичні захворювання |
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| цукровий діабет 2-го типу, Fanconi renotubular syndrome 4 with Maturity-onset diabetes of the young, rare genetic diabetes mellitus, maturity-onset diabetes of the young type 9[1] |
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| Реагує на сполуку |
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| лінолева кислота[2] |
| Онтологія гена |
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| Молекулярна функція | • DNA binding
• sequence-specific DNA binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• zinc ion binding
• зв'язування з іоном металу
• steroid hormone receptor activity
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• GO:0001948, GO:0016582 protein binding
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
• signaling receptor binding
• fatty acid binding
• protein homodimerization activity
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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| Клітинна компонента | • клітинне ядро
• цитоплазма
• нуклеоплазма
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| Біологічний процес | • triglyceride homeostasis
• ornithine metabolic process
• phospholipid homeostasis
• GO:0009373 regulation of transcription, DNA-templated
• SMAD protein signal transduction
• glucose homeostasis
• regulation of insulin secretion
• lipid metabolism
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• signal transduction involved in regulation of gene expression
• sex differentiation
• зсідання крові
• response to glucose
• transcription, DNA-templated
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• regulation of lipid metabolic process
• intracellular receptor signaling pathway
• regulation of growth hormone receptor signaling pathway
• negative regulation of cell growth
• lipid homeostasis
• xenobiotic metabolic process
• transcription initiation from RNA polymerase II promoter
• regulation of gastrulation
• steroid hormone mediated signaling pathway
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• negative regulation of cell population proliferation
• cholesterol homeostasis
• type B pancreatic cell development
• hepatocyte differentiation
• regulation of circadian rhythm
• GO:0045996 negative regulation of transcription, DNA-templated
• ритмічний процес
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | NM_000457
NM_001030003
NM_001030004
NM_001258355
NM_001287182
| NM_001287183
NM_001287184
NM_175914
NM_178849
NM_178850 |
| | NM_008261
NM_001312906
NM_001312907 |
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| RefSeq (білок) | NP_000448
NP_001025174
NP_001025175
NP_001245284
NP_001274111
| NP_001274112
NP_001274113
NP_787110
NP_849180
NP_849181 |
| | NP_001299835
NP_001299836
NP_032287 |
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| Локус (UCSC) | Хр. 20: 44.36 – 44.43 Mb | Хр. 2: 163.35 – 163.41 Mb |
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| PubMed search | [3] | [4] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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