MAP3K14

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Mitogenom-aktivirana protein kinaza kinaza kinaza 14
Identifikatori
SimboliMAP3K14; FTDCR1B; HS; HSNIK; NIK
Vanjski IDOMIM: 604655 MGI: 1858204 HomoloGene: 2940 GeneCards: MAP3K14 Gene
EC broj2.7.11.25
Ontologija gena
Molekularna funkcija • nukleotidno vezivanje
• aktivnost proteinske kinaze
• aktivnost proteinske serin/treonin kinaze
• proteinsko vezivanje
• ATP vezivanje
• aktivnost transferaze
Biološki proces • fosforilacija proteinskih aminokiselina
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez902053859
EnsemblENSG00000006062ENSMUSG00000020941
UniProtQ99558Q544K4
RefSeq (mRNA)NM_003954NM_016896
RefSeq (protein)NP_003945NP_058592
Lokacija (UCSC)Chr 17:
40.7 - 40.75 Mb		Chr 11:
103.04 - 103.08 Mb
PubMed pretraga[1][2]

MAP3K14 (Mitogenom-aktivirana protein kinaza kinaza kinaza 14, NF-kapa-B-indukujuća kinaza, NIK), je enzim koji je kod čoveka kodiran MAP3K14 genom.[1][2]

Funkcija

Ovaj gen kodira mitogenom-activiranu kinaza kinaza kinazu 14, koja je serin/treonin-specifična proteinska kinaza. Ova kinaza se vezuje za TRAF2 i stimuliše NF-κB aktivnost. Ona je kritična kinaza alternativnog NF-κB aktivacionog puta. Njena sekvenca je slična sa nekoliko drugih MAPKK kinaza. Ona učestvuje u NF-κB-indukovanoj signalnoj kaskadi koja je zajednička za receptore TNF/NGF) familije i za interleukinski-1 tip-I receptor.[2]

Interakcije

Za MAP3K14 je pokazano da interaguje sa TRAF2,[3][4] IKK2[3][5] i CHUK.[6][7][3][8]

Literatura

  1. ↑ Malinin NL, Boldin MP, Kovalenko AV, Wallach D (Mar 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature 385 (6616): 540–4. DOI:10.1038/385540a0. PMID 9020361. 
  2. ↑ 2,0 2,1 „Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14”. 
  3. ↑ 3,0 3,1 3,2 Luftig, M A; Cahir-McFarland E, Mosialos G, Kieff E (May 2001). „Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40”. J. Biol. Chem. (United States) 276 (18): 14602–6. DOI:10.1074/jbc.C100103200. ISSN 0021-9258. PMID 11278268. 
  4. ↑ Malinin, N L; Boldin M P, Kovalenko A V, Wallach D (February 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature (ENGLAND) 385 (6616): 540–4. DOI:10.1038/385540a0. ISSN 0028-0836. PMID 9020361. 
  5. ↑ Woronicz, J D; Gao X, Cao Z, Rothe M, Goeddel D V (October 1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK”. Science (UNITED STATES) 278 (5339): 866–9. DOI:10.1126/science.278.5339.866. ISSN 0036-8075. PMID 9346485. 
  6. ↑ Régnier, C H; Song H Y, Gao X, Goeddel D V, Cao Z, Rothe M (July 1997). „Identification and characterization of an IkappaB kinase”. Cell (UNITED STATES) 90 (2): 373–83. DOI:10.1016/S0092-8674(00)80344-X. ISSN 0092-8674. PMID 9244310. 
  7. ↑ Xiao, G; Sun S C (July 2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain”. J. Biol. Chem. (UNITED STATES) 275 (28): 21081–5. DOI:10.1074/jbc.M002552200. ISSN 0021-9258. PMID 10887201. 
  8. ↑ Ninomiya-Tsuji, J; Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway”. Nature (ENGLAND) 398 (6724): 252–6. DOI:10.1038/18465. ISSN 0028-0836. PMID 10094049. 

Dodatna literatura

  • Régnier CH, Song HY, Gao X, et al. (1997). „Identification and characterization of an IkappaB kinase.”. Cell 90 (2): 373–83. DOI:10.1016/S0092-8674(00)80344-X. PMID 9244310. 
  • Song HY, Régnier CH, Kirschning CJ, et al. (1997). „Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.”. Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. DOI:10.1073/pnas.94.18.9792. PMC 23270. PMID 9275204. 
  • Woronicz JD, Gao X, Cao Z, et al. (1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.”. Science 278 (5339): 866–9. DOI:10.1126/science.278.5339.866. PMID 9346485. 
  • Ling L, Cao Z, Goeddel DV (1998). „NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.”. Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3792–7. DOI:10.1073/pnas.95.7.3792. PMC 19916. PMID 9520446. 
  • Lee FS, Peters RT, Dang LC, Maniatis T (1998). „MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.”. Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. DOI:10.1073/pnas.95.16.9319. PMC 21336. PMID 9689078. 
  • Lin X, Mu Y, Cunningham ET, et al. (1998). „Molecular determinants of NF-kappaB-inducing kinase action.”. Mol. Cell. Biol. 18 (10): 5899–907. PMC 109176. PMID 9742107. 
  • Cohen L, Henzel WJ, Baeuerle PA (1998). „IKAP is a scaffold protein of the IkappaB kinase complex.”. Nature 395 (6699): 292–6. DOI:10.1038/26254. PMID 9751059. 
  • Aronsson FC, Magnusson P, Andersson B, et al. (1998). „The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.”. Hum. Genet. 103 (3): 340–5. DOI:10.1007/s004390050827. PMID 9799091. 
  • Nemoto S, DiDonato JA, Lin A (1998). „Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.”. Mol. Cell. Biol. 18 (12): 7336–43. PMC 109315. PMID 9819420. 
  • Li Y, Kang J, Friedman J, et al. (1999). „Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.”. Proc. Natl. Acad. Sci. U.S.A. 96 (3): 1042–7. DOI:10.1073/pnas.96.3.1042. PMC 15347. PMID 9927690. 
  • Lallena MJ, Diaz-Meco MT, Bren G, et al. (1999). „Activation of IkappaB kinase beta by protein kinase C isoforms.”. Mol. Cell. Biol. 19 (3): 2180–8. PMC 84010. PMID 10022904. 
  • Lin X, Cunningham ET, Mu Y, et al. (1999). „The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.”. Immunity 10 (2): 271–80. DOI:10.1016/S1074-7613(00)80027-8. PMID 10072079. 
  • Ninomiya-Tsuji J, Kishimoto K, Hiyama A, et al. (1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.”. Nature 398 (6724): 252–6. DOI:10.1038/18465. PMID 10094049. 
  • Delhase M, Hayakawa M, Chen Y, Karin M (1999). „Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.”. Science 284 (5412): 309–13. DOI:10.1126/science.284.5412.309. PMID 10195894. 
  • Hu WH, Johnson H, Shu HB (1999). „Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways.”. J. Biol. Chem. 274 (43): 30603–10. DOI:10.1074/jbc.274.43.30603. PMID 10521444. 
  • Yamamoto Y, Yin MJ, Gaynor RB (2000). „IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.”. Mol. Cell. Biol. 20 (10): 3655–66. DOI:10.1128/MCB.20.10.3655-3666.2000. PMC 85658. PMID 10779355. 
  • Xiao G, Sun SC (2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain.”. J. Biol. Chem. 275 (28): 21081–5. DOI:10.1074/jbc.M002552200. PMID 10887201. 
  • Chaudhary PM, Eby MT, Jasmin A, et al. (2000). „Activation of the NF-kappaB pathway by caspase 8 and its homologs.”. Oncogene 19 (39): 4451–60. DOI:10.1038/sj.onc.1203812. PMID 11002417. 
  • Kumar A, Eby MT, Sinha S, et al. (2001). „The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.”. J. Biol. Chem. 276 (4): 2668–77. DOI:10.1074/jbc.M008356200. PMID 11035039. 
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(1) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.1-EC 2.7.11.20)
Nespecifična serin/treonin proteinske kinaze (EC 2.7.11.1)
LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Proteinska kinaza B (AKT1, AKT2, AKT3), Ataksija telangiektazija mutirani, Sisarski cilj rapamicina, EIF-2 kinaze (PKR, HRI), Wee1 (WEE1)
Piruvat dehidrogenazna kinaza (EC 2.7.11.2)
Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3)
(3-metil-2-oksobutanoat dehidrogenaza (prenos acetila)) (EC 2.7.11.4)
BCKDK, BCKDHA, BCKDHB
(izocitrat dehidrogenaza (NADP+)) kinaza (EC 2.7.11.5)
IDH2, IDH3A, IDH3B, IDH3G
tirozin 3-monooksigenazna kinaza (EC 2.7.11.6)
Miozin-teški-lanac kinaza (EC 2.7.11.7)
Aurora kinaza (Aurora A kinaza, Aurora B kinaza)
Goodpasture-antigen-vezujuća proteinska kinaza (EC 2.7.11.9)
-
IκB kinaza (EC 2.7.11.10)
CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP
Proteinska kinaza A, PRKACG, PRKACB, PRKACA, PRKY
Protein kinaza C (EC 2.7.11.13)
Protein kinaza C, Protein kinaza Cζ, PKC alfa, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Proteinska zavisna proteinska N1, PKN2, PKN3,
Rodopsinska kinaza (EC 2.7.11.14)
Beta adrenergički receptor kinaza (EC 2.7.11.15)
Beta adrenergički receptor kinaza, Beta adrenergički receptor kinaza-2
Ca2+/kalmodulin-zavisna (EC 2.7.11.17)
BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1
MYLK, MYLK2, MYLK3, MYLK4
Fosforilazna kinaza (EC 2.7.11.19)
PHKA1, PHKA2, PHKB, PHKG1, PHKG2
Faktor elongacije 2 kinaza (EC 2.7.11.20)
Polo kinaza (EC 2.7.11.21)
PLK1, PLK2, PLK3, PLK4
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(2) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.21-EC 2.7.11.30)
Polo kinaza (EC 2.7.11.21)
PLK1, PLK2, PLK3, PLK4
Ciklin-zavisna kinaza (EC 2.7.11.22)
CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1
(RNK-polimerazna)-podjedinica kinaza (EC 2.7.11.23)
RPS6KA5, RPS6KA4, P70S6 kinaza, P70-S6 kinaza 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1
Ekstracelularnim signalom regulisane (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogenom-aktivirani protein (MAPK11, MAPK13, MAPK14)
MAP3K (EC 2.7.11.25)
MAP kinaza kinaza kinaze (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLK (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14
Tau-proteinska kinaza (EC 2.7.11.26)
TPK1, TTK, GSK-3
acetil-CoA karboksilazna kinaza] (EC 2.7.11.27)
-
Tropomiozinska kinaza (EC 2.7.11.28)
-
Receptor lipoproteina-niske-gustine kinaza (EC 2.7.11.29)
-
Receptor protein serin/treonin kinaza (EC 2.7.11.30)
Koštani morfogenetski proteinski receptori (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Mulerianski hormonski receptor
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(3) Kinaze dualne-specifičnosti (EC 2.7.12)
MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6