NOS3 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/d/de/PDB_1m9j_EBI.jpg/250px-PDB_1m9j_EBI.jpg) |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P |
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Identifiants |
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Aliases | NOS3, Nitric Oxyde Synthase 3 |
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IDs externes | OMIM: 163729 MGI: 97362 HomoloGene: 504 GeneCards: NOS3 |
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Position du gène (Homme) |
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![Chromosome 7 humain](//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/300px-Ideogram_human_chromosome_7.svg.png) | Chr. | Chromosome 7 humain[1] |
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| Locus | 7q36.1 | Début | 150,991,017 bp[1] |
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Fin | 151,014,588 bp[1] |
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Position du gène (Souris) |
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![Chromosome 5 (souris)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png) | Chr. | Chromosome 5 (souris)[2] |
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| Locus | 5 A3|5 11.32 cM | Début | 24,569,808 bp[2] |
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Fin | 24,589,472 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - rate
- apex of heart
- auricule droit
- upper lobe of left lung
- left uterine tube
- ventricule gauche
- body of uterus
- right lobe of thyroid gland
- artère coronaire gauche
- artère coronaire droite
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| Fortement exprimé dans | - ventricule droit
- subcutaneous adipose tissue
- tunica adventitia of aorta
- tunica media of zone of aorta
- tissu adipeux blanc
- endocardial cushion
- tissu adipeux brun
- muscle digastrique
- septum interventriculaire
- gastrula
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| Plus de données d'expression de référence |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/PBB_GE_NOS3_205581_s_at_fs.png/250px-PBB_GE_NOS3_205581_s_at_fs.png) | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - FMN binding
- actin monomer binding
- flavin adenine dinucleotide binding
- scaffold protein binding
- arginine binding
- tetrahydrobiopterin binding
- liaison ion métal
- fixation de la calmoduline
- liaison protéique
- heme binding
- NADP binding
- activité d'oxydoréductase
- cadmium ion binding
- nitric-oxide synthase activity
- NADPH-hemoprotein reductase activity
| Composant cellulaire | - cytoplasme
- endocytic vesicle membrane
- cytosol
- appareil de Golgi
- membrane
- Golgi membrane
- membrane plasmique
- Cavéole
- cytosquelette
- noyau
- membrane d'une vésicule
| Processus biologique | - negative regulation of muscle hyperplasia
- ovulation from ovarian follicle
- positive regulation of guanylate cyclase activity
- nitric oxide biosynthetic process
- regulation of systemic arterial blood pressure by endothelin
- regulation of sodium ion transport
- développement des poumons
- negative regulation of blood pressure
- removal of superoxide radicals
- regulation of nitric-oxide synthase activity
- mitochondrion organization
- response to heat
- in utero embryonic development
- negative regulation of hydrolase activity
- cell redox homeostasis
- arginine catabolic process
- response to fluid shear stress
- regulation of blood pressure
- negative regulation of platelet activation
- blood vessel remodeling
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- angiogenèse
- negative regulation of potassium ion transport
- nitric oxide mediated signal transduction
- negative regulation of calcium ion transport
- smooth muscle hyperplasia
- regulation of the force of heart contraction by chemical signal
- endothelial cell migration
- lipopolysaccharide-mediated signaling pathway
- negative regulation of cell population proliferation
- vasodilatation
- positive regulation of blood vessel endothelial cell migration
- positive regulation of angiogenesis
- aortic valve morphogenesis
- pulmonary valve morphogenesis
- endocardial cushion morphogenesis
- positive regulation of gene expression
- homeostasis of number of cells within a tissue
- ventricular septum morphogenesis
- negative regulation of biomineral tissue development
- response to hormone
- response to lipopolysaccharide
- regulation of nervous system process
- positive regulation of Notch signaling pathway
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_000603 NM_001160109 NM_001160110 NM_001160111 |
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RefSeq (protéine) | |
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NP_000594 NP_001153581 NP_001153582 NP_001153583 |
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Localisation (UCSC) | Chr 7: 150.99 – 151.01 Mb | Chr 5: 24.57 – 24.59 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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