UBE2E1

Protein-coding gene in the species Homo sapiens
UBE2E1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1XR9, 3BZH, 4JJQ

Identifiers
AliasesUBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
External IDsOMIM: 602916; MGI: 107411; HomoloGene: 84372; GeneCards: UBE2E1; OMA:UBE2E1 - orthologs
EC number2.3.2.24
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UBE2E1
Genomic location for UBE2E1
Band3p24.2Start23,805,955 bp[1]
End23,891,640 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for UBE2E1
Genomic location for UBE2E1
Band14|14 A1Start4,137,837 bp[2]
End4,186,974 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cartilage tissue

  • oral cavity

  • ventricular zone

  • embryo

  • skin of arm

  • superficial temporal artery

  • bronchial epithelial cell

  • mucosa of paranasal sinus

  • pons

  • lower lobe of lung
Top expressed in
  • otic placode

  • otic vesicle

  • saccule

  • mammillary body

  • ventral tegmental area

  • dorsomedial hypothalamic nucleus

  • arcuate nucleus

  • paraventricular nucleus of hypothalamus

  • nasal epithelium

  • olfactory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • ISG15 transferase activity
  • ubiquitin-protein transferase activity
  • protein binding
  • ATP binding
  • ubiquitin conjugating enzyme activity
Cellular component
  • cytosol
  • ubiquitin ligase complex
  • nucleoplasm
  • nucleus
Biological process
  • histone monoubiquitination
  • ubiquitin-dependent protein catabolic process
  • protein polyubiquitination
  • protein K48-linked ubiquitination
  • ISG15-protein conjugation
  • anaphase-promoting complex-dependent catabolic process
  • histone H2B ubiquitination
  • protein ubiquitination
  • regulation of mitotic cell cycle phase transition
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7324

22194

Ensembl

ENSG00000170142

ENSMUSG00000021774

UniProt

P51965

P52482

RefSeq (mRNA)

NM_001202476
NM_003341
NM_182666

NM_009455

RefSeq (protein)

NP_001189405
NP_003332
NP_872607
NP_003332.1

NP_033481

Location (UCSC)Chr 3: 23.81 – 23.89 MbChr 14: 4.14 – 4.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[5][6]

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

Interactions

UBE2E1 has been shown to interact with Ataxin 1[7] and NEDD4.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170142 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021774 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257.
  6. ^ a b "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".
  7. ^ Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907.
  8. ^ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. S2CID 1653536.
  9. ^ Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi:10.1074/jbc.C800030200. PMC 2276364. PMID 18287095.

Further reading

  • Pickart CM (2001). "Mechanisms underlying ubiquitination". Annu. Rev. Biochem. 70: 503–33. doi:10.1146/annurev.biochem.70.1.503. PMID 11395416.
  • Chen P, Johnson P, Sommer T, Jentsch S, Hochstrasser M (1993). "Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor". Cell. 74 (2): 357–69. doi:10.1016/0092-8674(93)90426-Q. PMID 8393731. S2CID 205020910.
  • Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. S2CID 1653536.
  • Nyman TA, Matikainen S, Sareneva T, Julkunen I, Kalkkinen N (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi:10.1046/j.1432-1327.2000.01433.x. PMID 10866800.
  • Lenk U, Sommer T (2000). "Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization". J. Biol. Chem. 275 (50): 39403–10. doi:10.1074/jbc.M006949200. PMID 10991948.
  • Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149.
  • Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894.
  • Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H (2005). "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin-conjugating enzyme E2 E1 (UBE2E1)


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  • 1y6l: Human ubiquitin conjugating enzyme E2E2
    1y6l: Human ubiquitin conjugating enzyme E2E2
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Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targeting
Ubiquitin
(ubiquitylation)
Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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