TXNL4A

Protein-coding gene in the species Homo sapiens

TXNL4A

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1PQN, 1QGV, 1SYX, 4BWQ, 4BWS, 4CDO, 3JCR

Identifiers

Aliases

TXNL4A, DIB1, DIM1, HsT161, SNRNP15, TXNL4, U5-15kD, BMKS, thioredoxin like 4A

External IDs

OMIM: 611595; MGI: 1351613; HomoloGene: 7150; GeneCards: TXNL4A; OMA:TXNL4A - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q23	Start	79,970,813 bp^[1]
Band	18q23	End	80,033,949 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

amygdala

right testis

left testis

endothelial cell

anterior pituitary

C1 segment

prefrontal cortex

gingival epithelium

right frontal lobe

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	U5 snRNP spliceosomal complex nucleoplasm nucleus cytosol nuclear membrane U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome
Biological process	RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cell cycle mRNA processing spliceosomal complex assembly cell division RNA splicing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10907


27366

Ensembl


ENSG00000141759


ENSMUSG00000057130

UniProt


P83876


P83877

RefSeq (mRNA)


NM_001303471 NM_001305557 NM_001305563 NM_001305564 NM_006701


NM_001038608 NM_001042408 NM_001042409 NM_025299 NM_178604

RefSeq (protein)


NP_001290400 NP_001292486 NP_001292492 NP_001292493 NP_006692

NP_001033697 NP_001035867 NP_079575 NP_848719 NP_001371102
NP_001371103 NP_001371104 NP_001371105 NP_001371106

Location (UCSC)

Chr 18: 79.97 – 80.03 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Thioredoxin-like protein 4A is a protein that is encoded by the TXNL4A gene in humans.^[4]^[5]

Interactions

TXNL4A has been shown to interact with PQBP1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141759 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (October 2000). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily". Physiol Genomics. 1 (3): 109–18. doi:10.1152/physiolgenomics.1999.1.3.109. PMID 11015569. S2CID 16086223.
^ "Entrez Gene: TXNL4A thioredoxin-like 4A".
^ Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (October 2000). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.

Reuter K, Nottrott S, Fabrizio P, Lührmann R, Ficner R (2000). "Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein". J. Mol. Biol. 294 (2): 515–25. doi:10.1006/jmbi.1999.3258. PMID 10610776.
Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (2001). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.
Zhang YZ, Cheng H, Gould KL, Golemis EA, Roder H (2003). "Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis". Biochemistry. 42 (32): 9609–18. doi:10.1021/bi034486i. PMID 12911302.
Laggerbauer B, Liu S, Makarov E, Vornlocher HP, Makarova O, Ingelfinger D, Achsel T, Lührmann R (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation" (PDF). RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Jin T, Guo F, Wang Y, Zhang YZ (2007). "Identification of human dim1 as a peptidase with autocleavage activity". Chemical Biology & Drug Design. 68 (5): 266–72. doi:10.1111/j.1747-0285.2006.00447.x. PMID 17177886. S2CID 13020526.