Protein-coding gene in the species Homo sapiens
| TRIM38 |
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| Identifiers |
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| Aliases | TRIM38, RNF15, RORET, tripartite motif containing 38 |
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| External IDs | MGI: 2684869; HomoloGene: 48427; GeneCards: TRIM38; OMA:TRIM38 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 6 (human)[1] |
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| | Band | 6p22.2 | Start | 25,962,802 bp[1] |
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| End | 25,991,231 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 13 (mouse)[2] |
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| | Band | 13|13 A3.1 | Start | 23,953,896 bp[2] |
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| End | 23,975,511 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - cardia
- renal medulla
- pylorus
- nipple
- buccal mucosa cell
- superior surface of tongue
- ventral tegmental area
- external globus pallidus
- vena cava
- trigeminal ganglion
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| | Top expressed in | - morula
- blastocyst
- jejunum
- zygote
- duodenum
- colon
- primary oocyte
- secondary oocyte
- embryo
- spermatid
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - zinc ion binding
- signal transducer activity
- metal ion binding
- protein binding
- transferase activity
| | Cellular component | - cytosol
- intracellular anatomical structure
| | Biological process | - immune system process
- interferon-gamma-mediated signaling pathway
- positive regulation of DNA-binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- protein ubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- innate immune response
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 6: 25.96 – 25.99 Mb | Chr 13: 23.95 – 23.98 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Tripartite motif containing 38 is a protein that in humans is encoded by the TRIM38 gene. [5]
Function
This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112343 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064140 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Tripartite motif containing 38". Retrieved 2018-03-21.
Further reading
- Liu X, Lei X, Zhou Z, Sun Z, Xue Q, Wang J, Hung T (February 2011). "Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase". Virol. J. 8: 61. doi:10.1186/1743-422X-8-61. PMC 3048563. PMID 21306652.
- Liu XL, Lei XB, Wang JW, Hong T (February 2011). "[Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways]". Zhonghua Shi Yan He Lin Chuang Bing du Xue Za Zhi (in Chinese). 25 (1): 60–2. PMID 21789858.
- Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T (2012). "TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation". PLOS ONE. 7 (10): e46825. Bibcode:2012PLoSO...746825X. doi:10.1371/journal.pone.0046825. PMC 3466175. PMID 23056470.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
