TAF1C

Protein-coding gene in the species Homo sapiens
TAF1C
Identifiers
AliasesTAF1C, MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C
External IDsOMIM: 604905; MGI: 109576; HomoloGene: 21163; GeneCards: TAF1C; OMA:TAF1C - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for TAF1C
Genomic location for TAF1C
Band16q24.1Start84,177,847 bp[1]
End84,187,070 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for TAF1C
Genomic location for TAF1C
Band8|8 E1Start120,324,610 bp[2]
End120,331,961 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ovary

  • right ovary

  • body of uterus

  • right lobe of thyroid gland

  • canal of the cervix

  • left lobe of thyroid gland

  • right uterine tube

  • spleen

  • gastric mucosa

  • apex of heart
Top expressed in
  • saccule

  • otic placode

  • otic vesicle

  • Ileal epithelium

  • internal carotid artery

  • external carotid artery

  • corneal stroma

  • crypt of lieberkuhn of small intestine

  • Rostral migratory stream

  • thymus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • RNA polymerase I core promoter sequence-specific DNA binding
Cellular component
  • RNA polymerase I transcription regulator complex
  • fibrillar center
  • nucleoplasm
  • nucleolus
  • nucleus
Biological process
  • termination of RNA polymerase I transcription
  • transcription initiation from RNA polymerase I promoter
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • regulation of transcription by RNA polymerase I
  • RNA polymerase I preinitiation complex assembly
  • transcription by RNA polymerase I
  • transcription elongation from RNA polymerase I promoter
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9013

21341

Ensembl

ENSG00000103168

ENSMUSG00000031832

UniProt

Q15572

Q6PDZ2

RefSeq (mRNA)
NM_001243156
NM_001243157
NM_001243158
NM_001243159
NM_001243160

NM_005679
NM_139353

NM_021441
NM_001378901

RefSeq (protein)
NP_001230085
NP_001230086
NP_001230087
NP_001230088
NP_001230089

NP_005670
NP_647610

NP_067416
NP_001365830

Location (UCSC)Chr 16: 84.18 – 84.19 MbChr 8: 120.32 – 120.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.[5][6]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[6]

Interactions

TAF1C has been shown to interact with UBTF.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103168 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031832 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID 7801123.
  6. ^ a b "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
  7. ^ Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. Bibcode:2001PNAS...9813631V. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
  8. ^ Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.

Further reading

  • Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID 10894955. S2CID 27014629.
  • Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
  • Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
  • Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
  • Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054. S2CID 8913931.
  • Friedrich JK, Panov KI, Cabart P, Russell J, Zomerdijk JC (2005). "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter". J. Biol. Chem. 280 (33): 29551–8. doi:10.1074/jbc.M501595200. PMC 3858828. PMID 15970593.
  • Zhang C, Comai L, Johnson DL (2005). "PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC 1190253. PMID 16055704.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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