STRN4

Protein-coding gene in the species Homo sapiens
STRN4
Identifiers
AliasesSTRN4, ZIN, zinedin, PPP2R6C, striatin 4
External IDsOMIM: 614767; MGI: 2142346; HomoloGene: 8378; GeneCards: STRN4; OMA:STRN4 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for STRN4
Genomic location for STRN4
Band19q13.32Start46,719,511 bp[1]
End46,746,994 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for STRN4
Genomic location for STRN4
Band7|7 A2Start16,549,814 bp[2]
End16,574,856 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • sural nerve

  • ganglionic eminence

  • stromal cell of endometrium

  • ventricular zone

  • body of uterus

  • granulocyte

  • muscle layer of sigmoid colon

  • apex of heart
Top expressed in
  • spermatocyte

  • dentate gyrus of hippocampal formation granule cell

  • spermatid

  • superior frontal gyrus

  • primary visual cortex

  • neural layer of retina

  • ventricular zone

  • internal carotid artery

  • hippocampus proper

  • external carotid artery
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein phosphatase 2A binding
  • protein binding
  • calmodulin binding
  • armadillo repeat domain binding
  • protein domain specific binding
  • protein-containing complex binding
Cellular component
  • cytoplasm
  • dendritic spine
  • protein phosphatase type 2A complex
  • cell projection
  • membrane
  • protein-containing complex
  • dendrite
  • FAR/SIN/STRIPAK complex
Biological process
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29888

97387

Ensembl

ENSG00000090372

ENSMUSG00000030374

UniProt

Q9NRL3

P58404

RefSeq (mRNA)

NM_001039877
NM_013403

NM_001039878
NM_133789

RefSeq (protein)

NP_001034966
NP_037535

NP_001034967
NP_598550

Location (UCSC)Chr 19: 46.72 – 46.75 MbChr 7: 16.55 – 16.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Striatin-4 is a protein that in humans is encoded by the STRN4 gene.[5][6]

Interactions

STRN4 has been shown to interact with STK24.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090372 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030374 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (Aug 2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi:10.1074/jbc.M909782199. PMID 10748158.
  6. ^ "Entrez Gene: STRN4 striatin, calmodulin binding protein 4".
  7. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. ^ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Gaillard S, Bartoli M, Castets F, Monneron A (2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Lett. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266. S2CID 7887096.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


  • v
  • t
  • e