SNX13

Gene of the species Homo sapiens

SNX13

Identifiers

Aliases

SNX13, RGS-PX1, sorting nexin 13

External IDs

OMIM: 606589; MGI: 2661416; HomoloGene: 41011; GeneCards: SNX13; OMA:SNX13 - orthologs

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[1]

Band	12\|12 A3	Start	35,097,185 bp^[1]
Band	12\|12 A3	End	35,197,478 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

n/a

Top expressed in

parotid gland

vastus lateralis muscle

otolith organ

triceps brachii muscle

utricle

lobe of cerebellum

temporal muscle

lacrimal gland

sternocleidomastoid muscle

cerebellar vermis

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphatidylinositol binding phosphatidylinositol-3-phosphate binding lipid binding
Cellular component	endosome early endosome early endosome membrane membrane
Biological process	protein transport negative regulation of signal transduction intracellular protein transport positive regulation of GTPase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23161


217463

Ensembl


ENSG00000071189


ENSMUSG00000020590

UniProt


Q9Y5W8


Q6PHS6

RefSeq (mRNA)


NM_015132


NM_001014973

RefSeq (protein)

NP_055947 NP_001337791 NP_001337792 NP_001337793 NP_001337795
NP_001337796 NP_001337797 NP_001337799


NP_001014973

Location (UCSC)

n/a

Chr 12: 35.1 – 35.2 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.^[4]^[5]^[6]

Function

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delays lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.^[6]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020590 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
^ Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (November 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science. 294 (5548): 1939–42. Bibcode:2001Sci...294.1939Z. doi:10.1126/science.1064757. PMID 11729322. S2CID 85169394.
^ ^a ^b "Entrez Gene: SNX13 sorting nexin 13".

Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Kosan C, Kunz J (2003). "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region". Cytogenetic and Genome Research. 97 (3–4): 167–70. doi:10.1159/000066618. PMID 12438708. S2CID 27223779.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.