Phosphatidylethanolamine binding protein 1

Protein-coding gene in the species Homo sapiens

PEBP1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1BD9, 1BEH, 2L7W, 2QYQ

Identifiers

Aliases

PEBP1, HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP, HEL-S-96, Phosphatidylethanolamine binding protein 1

External IDs

OMIM: 604591; MGI: 1344408; HomoloGene: 37637; GeneCards: PEBP1; OMA:PEBP1 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.23	Start	118,136,124 bp^[1]
Band	12q24.23	End	118,145,584 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 F\|5 56.88 cM	Start	117,420,719 bp^[2]
Band	5 F\|5 56.88 cM	End	117,425,690 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

renal medulla

postcentral gyrus

right adrenal cortex

left adrenal gland

left adrenal cortex

internal globus pallidus

superior frontal gyrus

Brodmann area 9

prefrontal cortex

superior vestibular nucleus

Top expressed in

testicle

spermatid

adrenal gland

mesencephalon

proximal tubule

spermatocyte

neural tube

dentate gyrus of hippocampal formation granule cell

hippocampus proper

lens

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding lipid binding nucleotide binding protein kinase binding phosphatidylethanolamine binding serine-type endopeptidase inhibitor activity ATP binding enzyme binding peptidase inhibitor activity RNA binding signaling receptor binding mitogen-activated protein kinase binding
Cellular component	cytoplasm cytosol nucleus extracellular exosome extracellular space mitochondrion mitochondrial outer membrane Golgi apparatus synaptic vesicle cell surface neuronal cell body myelin sheath axon terminus apical part of cell
Biological process	MAPK cascade negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of neurotransmitter levels regulation of the force of heart contraction response to oxidative stress human ageing response to heat response to wounding response to toxic substance response to organonitrogen compound response to activity hippocampus development negative regulation of MAPK cascade positive regulation of cAMP-mediated signaling response to ethanol positive regulation of mitotic nuclear division sperm capacitation response to corticosterone response to cAMP response to calcium ion positive regulation of acetylcholine metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5037


23980

Ensembl


ENSG00000089220


ENSMUSG00000032959

UniProt


P30086


P70296

RefSeq (mRNA)


NM_002567


NM_018858

RefSeq (protein)


NP_002558


NP_061346

Location (UCSC)

Chr 12: 118.14 – 118.15 Mb

Chr 5: 117.42 – 117.43 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene.^[5]^[6]

Interactions

Phosphatidylethanolamine binding protein 1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032959 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Park S, Yeung ML, Beach S, Shields JM, Yeung KC (May 2005). "RKIP downregulates B-Raf kinase activity in melanoma cancer cells". Oncogene. 24 (21): 3535–40. doi:10.1038/sj.onc.1208435. PMID 15782137. S2CID 25932498.
^ "Entrez Gene: PEBP1 phosphatidylethanolamine binding protein 1".
^ ^a ^b ^c Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (May 2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/mcb.20.9.3079-3085.2000. PMC 85596. PMID 10757792.

Schoentgen F, Jollès P (1995). "From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site". FEBS Lett. 369 (1): 22–6. doi:10.1016/0014-5793(95)00376-K. PMID 7641877. S2CID 25555428.
Ojika K, Mitake S, Tohdoh N, Appel SH, Otsuka Y, Katada E, Matsukawa N (2000). "Hippocampal cholinergic neurostimulating peptides (HCNP)". Prog. Neurobiol. 60 (1): 37–83. doi:10.1016/S0301-0082(99)00021-0. PMID 10622376. S2CID 13466181.
Odabaei G, Chatterjee D, Jazirehi AR, Goodglick L, Yeung K, Bonavida B (2004). Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. Advances in Cancer Research. Vol. 91. pp. 169–200. doi:10.1016/S0065-230X(04)91005-6. ISBN 9780120066919. PMID 15327891. {{cite book}}: |journal= ignored (help)
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Tohdoh N, Tojo S, Agui H, Ojika K (1995). "Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein". Brain Res. Mol. Brain Res. 30 (2): 381–4. doi:10.1016/0169-328X(95)00029-R. PMID 7637590.
Seddiqi N, Bollengier F, Alliel PM, Périn JP, Bonnet F, Bucquoy S, Jollès P, Schoentgen F (1994). "Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues". J. Mol. Evol. 39 (6): 655–60. Bibcode:1994JMolE..39..655S. doi:10.1007/BF00160411. PMID 7807553. S2CID 21554565.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hori N, Chae KS, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K (1994). "A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein". Gene. 140 (2): 293–4. doi:10.1016/0378-1119(94)90562-2. PMID 8144042.
Moore C, Perry AC, Love S, Hall L (1996). "Sequence analysis and immunolocalisation of phosphatidylethanolamine binding protein (PBP) in human brain tissue". Brain Res. Mol. Brain Res. 37 (1–2): 74–8. doi:10.1016/0169-328X(95)00285-Z. PMID 8738137.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Banfield MJ, Barker JJ, Perry AC, Brady RL (1998). "Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction". Structure. 6 (10): 1245–54. doi:10.1016/S0969-2126(98)00125-7. PMID 9782050.
Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W (1999). "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP" (PDF). Nature. 401 (6749): 173–7. Bibcode:1999Natur.401..173Y. doi:10.1038/43686. PMID 10490027. S2CID 4379551.
Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. PMC 85596. PMID 10757792.
Hengst U, Albrecht H, Hess D, Monard D (2001). "The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors". J. Biol. Chem. 276 (1): 535–40. doi:10.1074/jbc.M002524200. PMID 11034991.
Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904.
Maki M, Matsukawa N, Yuasa H, Otsuka Y, Yamamoto T, Akatsu H, Okamoto T, Ueda R, Ojika K (2002). "Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease". J. Neuropathol. Exp. Neurol. 61 (2): 176–85. doi:10.1093/jnen/61.2.176. PMID 11853019.
Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.

PDB gallery

1a44: PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN FROM CALF BRAIN
1b7a: STRUCTURE OF THE PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN FROM BOVINE BRAIN
1bd9: HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN
1beh: HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN IN COMPLEX WITH CACODYLATE