PPP6C

Protein-coding gene in the species Homo sapiens
PPP6C
Identifiers
AliasesPPP6C, PP6, PP6C, protein phosphatase 6 catalytic subunit
External IDsOMIM: 612725; MGI: 1915107; HomoloGene: 68273; GeneCards: PPP6C; OMA:PPP6C - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PPP6C
Genomic location for PPP6C
Band9q33.3Start125,146,573 bp[1]
End125,189,939 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PPP6C
Genomic location for PPP6C
Band2|2 BStart39,084,366 bp[2]
End39,116,463 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • sperm

  • secondary oocyte

  • gingival epithelium

  • parotid gland

  • buccal mucosa cell

  • palpebral conjunctiva

  • amniotic fluid

  • deltoid muscle

  • epithelium of nasopharynx
Top expressed in
  • medullary collecting duct

  • tail of embryo

  • genital tubercle

  • renal corpuscle

  • triceps brachii muscle

  • endocardial cushion

  • vastus lateralis muscle

  • spermatid

  • temporal muscle

  • morula
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • phosphoprotein phosphatase activity
  • hydrolase activity
  • metal ion binding
  • protein serine/threonine phosphatase activity
Cellular component
  • cytoplasm
  • cytosol
  • Golgi membrane
  • mitochondrion
Biological process
  • cell cycle
  • COPII vesicle coating
  • protein dephosphorylation
  • immune system process
  • innate immune response
  • G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5537

67857

Ensembl

ENSG00000119414

ENSMUSG00000026753

UniProt

O00743

Q9CQR6

RefSeq (mRNA)

NM_001123355
NM_001123369
NM_002721

NM_024209

RefSeq (protein)

NP_001116827
NP_001116841
NP_002712

NP_077171

Location (UCSC)Chr 9: 125.15 – 125.19 MbChr 2: 39.08 – 39.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene.[5][6]


Interactions

PPP6C has been shown to interact with IGBP1.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119414 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026753 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S (April 1997). "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics. 41 (2): 296–7. doi:10.1006/geno.1997.4640. PMID 9143513.
  6. ^ "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit".
  7. ^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, et al. (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
  8. ^ Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

Further reading

  • Bastians H, Ponstingl H (December 1996). "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation". Journal of Cell Science. 109 ( Pt 12) (Pt 12): 2865–74. doi:10.1242/jcs.109.12.2865. PMID 9013334.
  • Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Nasu-Nishimura Y, Hayashi T, Ohishi T, Okabe T, Ohwada S, Hasegawa Y, et al. (June 2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes to Cells. 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191. S2CID 7935936.
  • Stefansson B, Brautigan DL (August 2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". The Journal of Biological Chemistry. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.
  • Stefansson B, Brautigan DL (June 2007). "Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells". Cell Cycle. 6 (11): 1386–92. doi:10.4161/cc.6.11.4276. PMID 17568194.


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