PPP1R7

Protein-coding gene in the species Homo sapiens
PPP1R7
Identifiers
AliasesPPP1R7, SDS22, protein phosphatase 1 regulatory subunit 7
External IDsOMIM: 602877; MGI: 1913635; HomoloGene: 2032; GeneCards: PPP1R7; OMA:PPP1R7 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PPP1R7
Genomic location for PPP1R7
Band2q37.3Start241,149,576 bp[1]
End241,183,652 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PPP1R7
Genomic location for PPP1R7
Band1|1 DStart93,270,576 bp[2]
End93,301,211 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • nucleus accumbens

  • caudate nucleus

  • putamen

  • olfactory zone of nasal mucosa

  • sperm

  • right frontal lobe

  • right uterine tube

  • prefrontal cortex
Top expressed in
  • tail of embryo

  • dorsal striatum

  • olfactory tubercle

  • nucleus accumbens

  • genital tubercle

  • cingulate gyrus

  • seminiferous tubule

  • primitive streak

  • Region I of hippocampus proper

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • enzyme regulator activity
  • protein binding
  • protein phosphatase regulator activity
Cellular component
  • cytoplasm
  • extracellular exosome
  • nucleus
  • chromosome
Biological process
  • positive regulation of protein dephosphorylation
  • chromosome segregation
  • regulation of catalytic activity
  • regulation of phosphoprotein phosphatase activity
  • calcium activated phospholipid scrambling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5510

66385

Ensembl

ENSG00000115685

ENSMUSG00000026275

UniProt

Q15435

Q3UM45

RefSeq (mRNA)
NM_001282409
NM_001282410
NM_001282411
NM_001282412
NM_001282413

NM_001282414
NM_002712

NM_023200

RefSeq (protein)
NP_001269338
NP_001269339
NP_001269340
NP_001269341
NP_001269342

NP_001269343
NP_002703

NP_075689

Location (UCSC)Chr 2: 241.15 – 241.18 MbChr 1: 93.27 – 93.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1 regulatory subunit 7 is an enzyme that in humans is encoded by the PPP1R7 gene.[5][6][7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115685 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026275 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, Bollen M (Jan 1996). "Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1". FEBS Lett. 375 (1–2): 75–8. doi:10.1016/0014-5793(95)01180-M. PMID 7498485. S2CID 41223011.
  6. ^ Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM (Oct 1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map". Nat Genet. 10 (4): 415–23. doi:10.1038/ng0895-415. PMID 7670491. S2CID 22277955.
  7. ^ Ceulemans H, Van Eynde A, Perez-Callejon E, Beullens M, Stalmans W, Bollen M (Jun 1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1". Eur J Biochem. 262 (1): 36–42. doi:10.1046/j.1432-1327.1999.00344.x. PMID 10231361.
  8. ^ "Entrez Gene: PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7".

Further reading

  • Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry. 46 (31): 8909–19. doi:10.1021/bi7003119. PMID 17630778.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.


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