GUCY1A3

Protein-coding gene in the species Homo sapiens

GUCY1A1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3UVJ, 4NI2

Identifiers

Aliases

GUCY1A1, MYMY6, GC-SA3, GUCY1A3, GUCSA3, guanylate cyclase 1 soluble subunit alpha, guanylate cyclase 1 soluble subunit alpha 1, guanylate cyclase 1, soluble, alpha 3, GUC1A3, GUCA3

External IDs

OMIM: 139396; MGI: 1926562; HomoloGene: 37360; GeneCards: GUCY1A1; OMA:GUCY1A1 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q32.1	Start	155,666,711 bp^[1]
Band	4q32.1	End	155,732,349 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 E3	Start	81,999,734 bp^[2]
Band	3\|3 E3	End	82,053,096 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

urethra

vena cava

saphenous vein

visceral pleura

myocardium

right ventricle

superficial temporal artery

lower lobe of lung

lactiferous duct

middle temporal gyrus

Top expressed in

olfactory tubercle

left lung lobe

habenula

Gonadal ridge

ascending aorta

aortic valve

nucleus accumbens

atrium

atrioventricular valve

right lung lobe

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding guanylate cyclase activity GTP binding protein binding heme binding lyase activity phosphorus-oxygen lyase activity signaling receptor activity adenylate cyclase activity
Cellular component	cytoplasm plasma membrane guanylate cyclase complex, soluble glutamatergic synapse GABA-ergic synapse
Biological process	intracellular signal transduction cyclic nucleotide biosynthetic process blood circulation regulation of blood pressure cGMP biosynthetic process relaxation of vascular associated smooth muscle nitric oxide mediated signal transduction positive regulation of nitric oxide mediated signal transduction retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2982


60596

Ensembl


ENSG00000164116


ENSMUSG00000033910

UniProt


Q02108 Q6PJR4


Q9ERL9

RefSeq (mRNA)

NM_000856 NM_001130682 NM_001130683 NM_001130684 NM_001130685
NM_001130686 NM_001130687 NM_001256449


NM_021896 NM_001356987 NM_001356988

RefSeq (protein)

NP_000847 NP_001124154 NP_001124155 NP_001124156 NP_001124157
NP_001124159 NP_001243378 NP_001366595 NP_001366596 NP_001366597 NP_001366598 NP_001366599 NP_001366600 NP_001366601 NP_001366602 NP_001366603 NP_001366604 NP_001366605


NP_068696 NP_001343916 NP_001343917

Location (UCSC)

Chr 4: 155.67 – 155.73 Mb

Chr 3: 82 – 82.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.^[5]^[6]

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.^[6] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164116 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033910 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
^ ^a ^b "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

Giuili G, Roechel N, Scholl U, et al. (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486. S2CID 24237232.
Papapetropoulos A, Cziraki A, Rubin JW, et al. (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461. S2CID 25406282.
Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. doi:10.1042/bj3350051. PMC 1219751. PMID 9742212.
Zhou Y, Zheng JB, Gu X, et al. (2000). "A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?". Gene. 245 (2): 319–28. doi:10.1016/S0378-1119(00)00019-6. PMID 10717483.
Behrends S, Vehse K, Scholz H, et al. (2000). "Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 204–5. doi:10.1159/000015548. PMID 10828587. S2CID 5178613.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Saino M, Maruyama T, Sekiya T, et al. (2005). "Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3". Oncol. Rep. 12 (1): 47–52. doi:10.3892/or.12.1.47. PMID 15201957.
Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Phosphorus–oxygen lyases (EC 4.6)

4.6.1

Adenylate cyclase
(4.6.1.1)

intracellular	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY10
extracellular	Extracellular adenylate cyclase

Guanylate cyclase
(4.6.1.2)

soluble guanylyl cyclase	GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3
guanylate cyclase-coupled receptor	GUCY2C GUCY2D ANP (NPR1 NPR2)

Other

Cytidylate cyclase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Phosphatidylinositol diacylglycerol-lyase
Glycosylphosphatidylinositol diacylglycerol-lyase
FAD-AMP lyase (cyclizing)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)